FN 225: Nutrition
Noy Rathakette, Ph.D.
Health Professions Division
Lane Community College
Eugene, Oregon

LECTURE 6A: Protein
(Week 6)

EXAM 3 next week (Week 7).  Exams are always due THURSDAY and they will start being available on MONDAY.  If you need to take an exam late, please tell me BEFORE  the due date.


A commonly missed question on Exam 2 was the one that asked "According to how we've defined it in this class, what kind of food is white rice?" The choices were "whole", "partitioned" or "refined". The answer was "partitioned."




Exam 2: The range of scores for Exam 2 will be posted above Week 1 around Monday and you can see your score in the class after Exam 2.  Perhaps some of you still aren't accessing your Study Question results to see the correct answers, and looking at them could help improve your score on Exam 3.  If you haven't been doing this, review what it says on page 26 of your packet.

FORUM for Week 6:
  1. Take a look at the sources of Complete Protein chart on page 64 of your packet called "Food Sources of Carbohydrates, Lipids, Proteins".  What is ONE of your favorite foods on that list?

  2. Take a look at the sources of Incomplete Protein chart on page 64 of your packet called "Food Sources of Carbohydrates, Lipids, Proteins".  What is ONE of your favorite foods on that list?

  3. Do you have any questions about Lecture 6A or the Study Questions for Chapter 6?

  4. One of my goals for this class is to create a connected classroom community even though we're meeting in cyberland and maybe that's why I was so moved by this video, aired on TV on October 24, 2008. 

    After visiting a neighborhood in New York City, Bill Moyers talks with Mark Johnson, the producer of a remarkable documentary about the joy and connection music can bring to our global community.  If you have trouble watching this 19-minute video, look at the help buttons.

    What do you think about the "Playing for Change" project depicted in this video?

    http://www.pbs.org/moyers/journal/10242008/watch3.html

    NPR's Morning Edition show had this story on May 4, 2009: 'Playing For Change' And Peace Through Music

    http://www.npr.org/templates/story/story.php?storyId=103715874

LECTURE 6A: Protein

First skim through the Lecture Outline:
I  Introduction
II  The Structure of Amino Acids & Protein
III    FUNCTIONS of Protein
IV  Protein in the Diet- Quality
V  Problems with Protein Quantity
VI     Digestion of Protein
VII    Using Amino Acids

While you're waiting for the first Video Clip for this lecture to buffer, go to page 86 in your packet and fill in the figures below.  We'll talk about those numbers later.

Figures below are were downloaded in about 2005 from:
http://globalis.gvu.unu.edu/ , an online interactive world atlas that is "a collaboration between the Norwegian UN Association, UNEP/GRID-Arendal, UNU/Global Virtual University, the University College of Hedmark and the INTIS schools. The project is supported by the Norwegian Ministry of Foreign Affairs and the Norwegian Agency for Development Cooperation."

/


1960  1990 2002
Afghanistan 245 168 165
Malawi 205 146 113
Haiti 169 102 79
Iraq 117
40 102
Cuba 39 12 7
U.S. 26 9 7
Sweden
16
6
3
Other countries with IMRs 3 or 2 as of 2005: Norway, Finland, Japan, Hong Kong, Iceland and Singapore, who has the lowest IMR







Notes About CUBA:
Since it's an example of an communist country, Cuba's is an interesting statistic for Infant Mortality Rate.  Most Cuban citizens live in poverty, with many factors contributing to this.  Some feel one factor is the 70-year leadership of Fidel Castro.

Many others feel a factor is the United States Embargo Against Cuba, an economic, commercial, and financial embargo imposed on Cuba on February 7, 1962.

In February, 2008, Fidel turned over power to his brother, Raúl.  Eduardo Machado, a Cuban playwright living in the United States, says "My hope is that Cuba is allowed to become a part of the world again while keeping the social reforms that the revolution is so proud of: free education for all and free health care."
Cuban Exile Ponders Life After Castro, by Eduardo Machado, National Public Radio, February 23, 2008.

Cuba limits sales of food so all can eat, Associated Press, MSNBC, Oct. 10, 2008. "The lines are long and some foods are scarce, but because the government has maintained and even increased rations in some areas, Cubans who initially worried about getting enough to eat now seem confident they won't go hungry despite the destruction of 30 percent of the island's crops by hurricanes Gustav and Ike last month."

Notes About IRAQ:
Notice that is the most recent date on the above table is 2002, which was before the 2003 U.S. invasion of Iraq.  In 1990, the United Nations Security Council passed a comprehensive ban on trade with Iraq.  A devastating bombing campaign against Iraq in 1991 destroyed the country's civilian infrastructure (leading to contaminated drinking water, lack of electricity for hospitals

As of March 2003 (just prior to the war), between 1.7 and 2 million Iraqi civilians have died due to malnutrition and disease, about 700,000 of them are children.  

Notice in the above table what happened to IMR in Iraq between 1990 and 2002.


This over 12-year embargo on Iraq was lifted in 2003 by the United Nations.  I have not been able to find a current IMR for Iraq.  Please let me know if you know anything about the current IMR in Iraq.



Now, go to the bottom of page 85 in your packet to the section about

B.  Protein Deficiency: Global Hunger

Since the first cells to suffer from protein deficiency are those that are replaced most often, including red blood cells, plasma proteins as well as inner and outer skin cells, you would expect early symptoms to be problems affecting
blood
the digestive tract since it's inner "skin"
outer skin

Protein deficiency usually usually happens when someone isn't getting enough food, so that means they ALSO aren't getting enough calories and they have something called PEM (it's also known as PCM).  There are two forms of PCM.
The protein deficiency part is called kwashiorkor, a beautiful word from Ghana in Africa  that means "the evil disease that strikes the first child when the second child is born.  In other words, weaning.  It is possible to nurse 2 children, but it takes a well-nourished mother to do it.

When the child is weaned a mother who is very poor can probably manage just a thin cereal to feed her first child.  The child may get barely enough calories, but not enough protein.  That's the situation below for the child below who has kwashiorkor.  Notice the edema (fluid buildup) at the ankles and wrists as well as the skin problems.  I'll explain the edema in one of the Video Clips.  On the right is the same child once protein was added to his diet.

01kwashiorkor

Sometimes a person gets enough protein, but not enough calories.  That person has marasmus, shown below with the girl with anorexia nervosa.

02marasmus

The mother and child shown below have BOTH a deficiency of calories and
a deficiency of protein, so they both have PCM (PEM).  Notice the abdominal edema (called ascites) in the child.

03pcmsudanmotherson
Now go back to page 83 in your packet and watch the following two Video Clips to help with

I  Introduction
II  The Structure of Amino Acids & Protein
III    FUNCTIONS of Protein

on page 83 and 84.


Video Clip: Amino Acids & Proteins
approximately 11 minutes
The two browsers that seem to be the fastest ways of accessing the video clips are Safari on a Mac and Internet Explorer on a Windows-based computer. 

If
the movie just above isn't showing up on your computer and the movie just below  isn't showing up on your computer, you may not have the latest version of QuickTime on your computer.  Click here to download the newest version of Quick Time.



This next Video Clip mentions denaturation, which is also discussed later, on page 86 where the definition of denaturation is given.

The Video Clip does not answer the question on page 83 at
D.    What the body uses to assemble the proteins it needs are amino acids.
Video Clip: Proteins
approximately 16 minutes


The above Video Clip doesn't mention the following parts of your Lecture Outline.

Additional functions of proteins include:

5.    Antibodies.  
Antibodies are proteins, so a person needs protein in the diet in order to supply amino acids to build antibodies.  Antibodies fight infection.

6.    Energy.
We usually use glucose & fat for energy before using protein.
 

The important way the muscles help provide energy for the brain is by having their amino acids rearranged to become glucose for the brain.  Our brain cannot use fat for energy, at least not in any significant amount.

The following is an emerging use for proteins that I want to learn more about.
Biomarkers: 'I'm Pretty Optimistic'; "...medical researchers are excited about the potential for diagnostic techniques involving proteins--workhorse molecules that carry out myriad tasks required to keep the human body functioning. Each disease may trigger its own unique set of protein "biomarkers," which doctors might someday be able to detect in simple blood tests." Newsweek, Dec. 11, 2006.


IV  
Protein in the Diet- Quality

Measures of Protein Quality in a food include digestibility and how well the amino acid pattern of the protein supports growth.

A.    Digestibility.  Animal protein is more digestible than plant protein.

B.    Amino Acid Pattern     
Take a look at these 2 definitions in your Lecture Outline on page 84 of your packet.
1.    Complete protein       
This is a protein in food that has all the ESSENTIAL amino acids (in the needed proportions) for building protein in the cells of the body.   Food sources for complete protein are listed on page 64 in your packet.  A chicken puts protein in its eggs for the same reason we need to eat protein- to provide amino acids to build proteins.  In other words, the developing chick will get amino acids out of that yolk and white, then uses those amino acids to build the proteins it needs for muscles, bones, enzymes, hormones, etc.

2.    Incomplete protein       
This is a protein in food that is missing enough of one or more of the essential amino acids needed for the building of protein in the body's cells.

Now look at the packet handout Food Sources Carbohydrates, Lipids, Proteins (page 64) and refer to it as you're watching the next Video Clip and filling in your Lecture Outline.



Video Clip: Complete & Incomplete Proteins
approximately 16 minutes
This Video Clip will help you answer the Study Question about why kidney beans have more protein than green beans.  

The two browsers that seem to be the fastest ways of accessing the video clips are Safari on a Mac and Internet Explorer on a Windows-based computer. 

If
the movie isn't showing up on your computer, you may not have the latest version of QuickTime on your computer.  Click here to download the newest version of Quick Time.

Sometimes students have trouble opening the Video Clip below.  If that's the case for you, please send me a message and I can suggest another way to get it.



3.    Mutual Supplementation Proteins-

2 incomplete proteins that when combined form complete protein (legume + grain)

A good example of
Mutual Supplementation would be a bean burrito.  The tortilla would be a grain source and the beans would be the legume.

Another example
of Mutual Supplementation would be split pea soup & cornbread, as split peas are legumes.

Green beans with a dinner roll would be a poor example of Mutual Supplementation because the green beans haven't had much time to manufacture protein the way a kidney bean would, as explained in a previous Video Clip. 

The
oatmeal & milk would be a fine way to get protein, but they are NOT an example of Mutual Supplementation because the milk has complete protein and Mutual Supplementation involves 2 incomplete proteins.


V  Problems with Protein Quantity
(as opposed to the last section which looked at
Protein Quality)

A.     Problems with high protein levels in your diet:     
1.    Amine group (the N part) of extra amino acids:
Below is aspartic acid, an amino acid we looked at earlier when we said all amino acids have 4 parts.  One part is the amine group and the other 3 parts have carbon (1- Central C & H, 2-acid groups (COOH) & 3- side chains). First the amine group.

Aspartic Acid

     

The amine group (NH2) is pulled off by the liver & excreted by the kidney, which can be hard on he liver and kidney.  
     
2.    Central C & H, acid groups (COOH) & side chains (mostly C, H, O)

are used for energy if you need it OR if the calories are extra, it is changed into fat.

     
3.    High protein diets may accelerate adult bone loss by causing calcium loss.

Click here for Part 2 of LECTURE 6A.